causes of progressive lipodystrophy, what are the causes of progressive lipodystrophy

causes of progressive lipodystrophy, what are the causes of progressive lipodystrophy

  • 2021-10-28 18:49:09
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Causes of progressive lipodystrophy

Causes of progressive lipodystrophy

1. Causes of disease

The cause is unknown. It can be caused by the damage of the midbrain and diencephalon, resulting in increased secretion of hormones in the anterior pituitary gland or disorder of mesodermal mesenchymal function development. Sissons found that some patients had glomerulonephritis and hypocomplement (C3)emia. A few patients have a family history.

2. Pathogenesis

Mainly related to hypothalamic lesions and postganglionic sympathetic neuropathy parallel to spinal nerves. Hypothalamus regulates gonadotropin, thyroid-stimulating hormone and other endocrine glands, and has close anatomical connection with postganglionic sympathetic nerve fibers. There seems to be a boundary between the adipose tissue disappearance area of ​​progressive lipodystrophy and the normal area or obesity area. The boundary seems to have a certain relationship with the spinal cord segment. The body is usually divided into upper body and lower body with waist 1~2 as the boundary. Two parts.

Another study believes that the hypothalamus and pituitary constitute a metabolic regulation and control system, and the loss of fat is related to the promotion of fat transfer factors produced by this system. There may be a history of acute fever and endocrine defects before the onset of illness, such as hyperthyroidism, hypopituitarism, and diencephalitis. Injury, mental factors, early menstruation and pregnancy can all be triggers. At present, there is no unified view on the role of genetic factors. .

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